Injectable Nano-Network for Glucose-Mediated Insulin Delivery Pubs.acs.org

Schematic of the glucose-responsive nano-network. (a) Nanoparticles (NPs) encapsulating insulin and glucose-specific enzymes (GOx, glucose oxidase; CAT, catalase) are made of acidic sensitive acetal-modified dextran (b) and coated with chitosan and alginate, respectively. (c) Nano-network (NN) is formed by mixing oppositely charged nanoparticles together and efficiently degrades to release insulin upon the catalytic generation of gluconic acid under hyperglycemic conditions. (d) Schematic of glucose-mediated insulin delivery for type 1 diabetes treatment using the STZ-induced diabetic mice model.

Injectable Nano-Network for Glucose-Mediated Insulin Delivery
Zhen Gu, Alex A. Aimetti, Qun Wang, Tram T. Dang, Yunlong Zhang, Omid Veiseh, Hao Cheng, Robert S. Langer, and Daniel G. Anderson
ACS Nano 2013 7 (5), 4194-4201

Fuente: Pubs.Acs.org