Encapsulation Encapsulate your precious active compound!
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What is Encapsulation?
Encapsulation is the immobilization of active ingredients in a polymer matrix. The active compounds which are immobilized are for example enzymes, drugs, flavors & fragrances, vitamins, oils, cells or microbes.
There is a wide range of polymer matrices which can be utilized such as alginate, carrageen, cellulose sulphate, chitosan, gelatine or pectin, as well as waxes. The polymer matrix is used as a protection shield or as a barrier through which only specific compounds can diffuse.
Uniform beads and capsules with high reproducibility are produced with the sophisticated encapsulation technology provided by BUCHI. Their size is pre-selectable in the range of 0.15 mm to 2 mm with a spherical shape, a narrow size distribution (< 5% standard deviation) and a productivity of up to 6’000 beads per second.
Why Encapsulation?
Encapsulation is gaining greater attention as a mild, continuous and scalable process. It is particularly used to protect or stabilize drugs, microorganisms, enzymes or cells in a polymeric matrix.
The wide variety of polymer matrices allows the construction of beads with specific features. Hydrogel matrices have an open pore structure so that small hydrophilic molecules like peptides diffuse freely in and out. However, lipophilic molecules or large hydrophilic molecules like proteins remain immobilized in the matrix. The diffusion behavior of mole cules in and out of the bead can be modified by the addition of a secondary membrane. This possibility is very helpful in cell transplantation to reject the host immune system at the bead surface. Therefore foreign implanted cells are protected against the host immune system.
Biodegradable polymers allow the construction of slow release formulations. The uniform bead size, which is especially achievable with the Encapsulator, offers better modification options of the release profile.
Encapsulation is the immobilization of active ingredients in a polymer matrix. The active compounds which are immobilized are for example enzymes, drugs, flavors & fragrances, vitamins, oils, cells or microbes.
There is a wide range of polymer matrices which can be utilized such as alginate, carrageen, cellulose sulphate, chitosan, gelatine or pectin, as well as waxes. The polymer matrix is used as a protection shield or as a barrier through which only specific compounds can diffuse.
Uniform beads and capsules with high reproducibility are produced with the sophisticated encapsulation technology provided by BUCHI. Their size is pre-selectable in the range of 0.15 mm to 2 mm with a spherical shape, a narrow size distribution (< 5% standard deviation) and a productivity of up to 6’000 beads per second.
Why Encapsulation?
Encapsulation is gaining greater attention as a mild, continuous and scalable process. It is particularly used to protect or stabilize drugs, microorganisms, enzymes or cells in a polymeric matrix.
The wide variety of polymer matrices allows the construction of beads with specific features. Hydrogel matrices have an open pore structure so that small hydrophilic molecules like peptides diffuse freely in and out. However, lipophilic molecules or large hydrophilic molecules like proteins remain immobilized in the matrix. The diffusion behavior of mole cules in and out of the bead can be modified by the addition of a secondary membrane. This possibility is very helpful in cell transplantation to reject the host immune system at the bead surface. Therefore foreign implanted cells are protected against the host immune system.
Biodegradable polymers allow the construction of slow release formulations. The uniform bead size, which is especially achievable with the Encapsulator, offers better modification options of the release profile.
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